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This CME/CE activity is provided by PRIME Education, Inc. (PRIME®) and is accredited for a multi-disciplinary audience of health care practitioners. This activity is supported by contract number HHSA290201200021I from the Agency for Healthcare Research and Quality. User data collected through this activity will reside on PRIME's educational portal for use by AHRQ.

AHRQ's Comparative Effectiveness Research on Angiotensin-Directed Therapies for Stable Ischemic Heart Disease: Applying the Results in Practice

Credit for this CME/CE activity has expired.

You can still access the program, but will not receive a certificate.

Program Overview

Activity Description

Stable ischemic heart disease (IHD) is a condition of advanced atherosclerosis in which affected individuals may be asymptomatic or may experience debilitating symptoms, including angina and diminished activity tolerance. Stable IHD significantly increases the risks of nonfatal and fatal cardiovascular events. Considerable evidence from clinical trials has demonstrated that standard medical treatments - including antiplatelet therapy, statins, beta-blockers, and vasodilators - partially reduce risks and/or symptoms in patients with stable IHD. The evidence is less clear about the effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs), especially in patients with stable IHD who have no history of heart failure or left ventricular dysfunction. For this population a key clinical question is whether, compared with standard medical therapy alone, the addition of an ACEI or ARB is beneficial and safe. Another question involves the benefits and harms of combined regimens of these angiotensin-directed therapies. These questions are central to a systematic research review that was commissioned by the Agency for Healthcare Research and Quality (AHRQ) and published in 2009. The findings and clinical applications of the AHRQ review are presented in this educational activity.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Summarize the comparative effectiveness and safety of adding an ACEI or an ARB to standard therapy versus standard therapy alone
  • Compare the benefits and harms of ACEI-ARB combined therapy plus standard therapy versus an ACEI or an ARB plus standard therapy
  • Identify characteristics and clinical conditions of patients who might benefit from adding an ACEI, an ARB, or ACEI-ARB combined therapy to standard therapy
  • Apply the systematic review findings to make appropriate patient-centered treatment decisions and to counsel patients about individualized treatment options

Target Audience

This CME activity is designed to meet the educational needs of physicians, nurse practitioners, pharmacists, nurses, case managers, medical assistants, health education specialists.

Method of Participation

To receive a certificate for this activity, you should:

  • Complete the learner assessment pretest
  • View the entire activity online (Hardware/Software Requirements: Broadband & Flash Player or HTML5 browser)
  • Complete an online evaluation & post-test
  • Print your certificate online

The estimated time to complete this activity, including review of the materials, is 1.0 hour.

Term of Approval

June 30, 2011 through June 29, 2013. Original release date: June 30, 2011.

Acknowledgement of Support

There is no fee for this CME/CE activity. This activity is sponsored by PRIME Education, Inc (PRIME®) and funded under contract HHSA290201200021I from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health and Human Services (HHS).

Faculty Biographies and Disclosures

Click faculty name to view full biography.

Speaker

C Michael White PharmD, FCP, FCCP
Professor and Head, School of Pharmacy,

University of Connecticut, Storrs, CT
Director, University of Connecticut, Hartford Hospital EPC
Storrs, CT

Speaker

Gary L Schaer, MD
Professor of Medicine
Director, Cardiac Catheterization Lab
Rush University Medical Center
Chicago, IL

Planner

Carolyn LePage, PhD, ARNP
Assistant Professor
Barry University School of Nursing
Miami Shores, FL

Planner

Heidi Wynn Maloni, PhD, ANP-BC, CNRN, MSCN
National Clinical Nursing Director
Department of Neurology
Multiple Sclerosis Center of Excellence, East Veterans Affairs Medical Center
Adjunct Faculty
Trinity Nursing Program School of Professional Studies, Trinity Washington University
Clinical Preceptor and Instructor
Advanced Practice Programs, The Catholic University of America School of Nursing
Washington, DC

Planner

Wanda F Carter, MPH, CHES
Community Collaboration Manager
Wellpoint, Inc
Adjunct Professor, Axia College (U of Phoenix) Health Care Administration Program
Adjunct Professor, Ashford University Health Care Administration Program
PHPS Alumnus, CDC Scientific Education and Professional Development Program Office
Lawrenceville, GA

Peer Reviewer

Donna M Chiefari, BSc (Pharm), PharmD, RPh, FASHP
Adjunct Faculty & Preceptor
Albany College of Pharmacy
Albany, NY

Peer Reviewer

Joyce M Knestrick, PhD, CRNP, FAANP
Online Program Director
Associate Professor Georgetown University
Family Nurse Practitioner at Wheeling Health Right
Wheeling, WV

Peer Reviewer

Kathleen A Jarvis, MS, RN, CCM
Clinical Educator
Alere Healthcare
Fort Lauderdale, FL

Peer Reviewer

Sherman Podolsky, MD
Medical Director
Superior HealthPlan
Former Chairman
Department of Emergency Medicine
Albert Einstein Medical Center
Philadelphia, PA

Begin Activity

Accreditation/Credit Designation

This program is no longer accredited.

Begin Activity

Faculty Disclosures

Faculty Name
Advisory Board Consultant Grants / Research Salary / Contractual Supported Promotional Education Stock / Shareholder Other Financial Support
C Michael White PharmD, FCP, FCCP
Author
None None None None None None None
Gary L Schaer, MD
Author
None None None None None None None
Carolyn LePage, PhD, ARNP
Planner
None None None Barry University None None None
Heidi Wynn Maloni, PhD, ANP-BC, CNRN, MSCN
Planner
None None None None None None None
Wanda F Carter, MPH, CHES
Planner
None None None None None None None
Donna M Chiefari, BSc (Pharm), PharmD, RPh, FASHP
Reviewer
None None None None None None None
Joyce M Knestrick, PhD, CRNP, FAANP
Reviewer
None None None None None None None
Kathleen A Jarvis, MS, RN, CCM
Reviewer
None None None None None None None
Sherman Podolsky, MD
Reviewer
None None None None None None None
Chris R Prostko, PhD
Scientific Program Director
NoneNoneNonePRIME®NoneNoneNone
Lynn Goldenberg, RN, BSN
Director of Accreditation & Compliance
NoneNoneNonePRIME®NoneNoneNone

Disclosure Policy

PRIME Education Inc (PRIME®) endorses the standards of the ACCME, as well as those of the AANP, ANCC and ACPE, that require everyone in a position to control the content of a CME/CE activity to disclose all financial relationships with commercial interests that are related to the content of the CME/CE activity. CME/CE activities must be balanced, independent of commercial bias and promote improvements or quality in healthcare. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession.

A conflict of interest is created when individuals in a position to control the content of CME/CE have a relevant financial relationship with a commercial interest which therefore may bias his/her opinion and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks or other financial benefits.

PRIME® willidentify, review and resolve all conflicts of interest that speakers, authors, course directors, planners, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for speakers, authors, course directors, planners, peer reviewers, and/or relevant staff are provided with this activity.

Presentations that provide information in whole or in part related to non FDA approved uses of drugs and/or devices will disclose the unlabeled indications or the investigational nature of their proposed uses to the audience. Participants should refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Participants should verify all information and data before treating patients or employing any therapies prescribed in this educational activity. The opinions expressed in the educational activity are those of the presenting faculty and do not necessarily represent the views of PRIME®, the ACCME, AANP, ACPE, ANCC and other relevant accreditation bodies.

Content validation methods are consistently utilized by PRIME® to ensure that all program content is evidence-based, fair-balanced, and developed with scientific rigor and integrity. All clinical recommendations are based on evidence accepted within the medical profession. All scientific research referred to, reported or used to support a clinical recommendation conforms to accepted standards of experimental design, data collection and analysis. In addition to review of content by course directors and expert faculty, content is also validated through independent peer reviewers selected for their expertise in the content area, as well as their experience in the intended audience. All peer reviewers, planners, course directors, faculty and relevant staff utilized by PRIME® complete disclosures which are related to their role in the educational activity.

Accessibility

PRIME®is committed to providing access to our CME programs for individuals with disabilities as identified in Section 508 of the Rehabilitation Act for all web-based programs. This website is 508 compliant.

Begin Activity

Video Presentation

To play the video below, your device must support HTML5 video (ex: iPad, Android, Chrome) or have Adobe Flash Player installed. Closed captioning is available by clicking the "CC" button in the top right of the video player.

Post-Test & Evaluation

Credit for this program has expired.

If you already completed this program and need to reprint your certificate(s), login here.

Clinician & Consumer Summaries on ACEIs and ARBs

Download these free summaries for your reference and/or patient handouts. You may also order bulk copies free of charge from the AHRQ Publication Clearinghouse below.

AHRQ Clearinghouse Bulk Order Form

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  • Alternatively, you can call the AHRQ Publications Clearinghouse at 1-800-358-9295. Reference the title and product number above.