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This CME/CE activity is provided by PRIME Education, Inc. (PRIME®) and is accredited for a multi-disciplinary audience of health care practitioners. This activity is supported by contract number HHSA290201200021I from the Agency for Healthcare Research and Quality. User data collected through this activity will reside on PRIME's educational portal for use by AHRQ.

Understanding Comparative Effectiveness Research and Applicability to Practice

To Receive a Certificate for This Activity:

Course Image
  1. 1. Read the Program Overview on this page.
  2. 2. Review the Faculty Biographies, Accreditation Statements, and Disclosure tabs.
  3. 3. Access the Activity in full.
  4. 4. Complete the Post-Test & Evaluation.
  5. 5. A printable certificate will be available immediately following the activity.

Program Overview

Activity Description

Over the last several decades, advancements in science and medicine have led to a major expansion in the armamentarium of treatments for many diseases. With the progression of therapies and medicines, the number of scholarly journals and peer-reviewed journal articles reporting on clinical trials has increased substantially. While it is essential for clinicians to remain up-to-date with the latest clinical research, finding the time to read the plethora of published articles can be difficult. In an effort to condense the large quantity of literature and guide informed decisionmaking for the improvement of patient outcomes, the Agency for Healthcare and Research Quality began conducting systematic reviews comparing the efficacy and safety of various interventions for diseases. A panel of clinician stakeholders present an overview describing the process for conducting comparative effectiveness in research, in addition to presenting educational materials associated with each review, and detailing the applicability of review findings in clinical practice.

Learning Objectives

At the conclusion of this activity, the participant should be able to:

  • Describe the AHRQ's role for improving the quality of healthcare and providing evidence-based reports for consumers and clinicians
  • Identify the principles and framework used by the AHRQ for conducting comparative effectiveness research
  • Demonstrate ways to apply research materials into quality, safety, and shared clinical decision-making efforts for use in clinical practice
  • Recognize partners' role in implementing evidence-based medicine

Target Audience

This CME activity is designed to meet the educational needs of physicians, physician assistants, pharmacists, nurse practitioners, nurses, case managers, health education specialists and medical assistants.

Method of Participation

To receive a certificate for this activity, you should:

  • Complete the learner assessment pretest
  • View the entire activity online
  • Complete an online evaluation & post-test
  • Print your certificate online

The estimated time to complete this activity, including review of the materials, is 1.0 hour.

Term of Approval

April 30, 2012 through April 29, 2014. Original release date: April 30, 2012.

Acknowledgement of Support

There is no fee for this CME/CE activity. This activity is sponsored by PRIME Education, Inc (PRIME®) and funded under contract HHSA290201200021I from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health and Human Services (HHS).

Faculty Biographies and Disclosures

Click faculty name to view full biography.


C Michael White PharmD, FCP, FCCP
Professor and Head, School of Pharmacy,

University of Connecticut, Storrs, CT
Director, University of Connecticut, Hartford Hospital EPC
Storrs, CT


L. Natalie Carroll, MD, FACOG
Associate Clinical Instructor
University of Texas Health Science Center
Memorial Hermann Hospital
Houston, TX


Lucy N Marion, PhD, RN, MN, FAAN
Dean and Professor
Medical College of Georgia
Augusta, Georgia


Barbara L Kass, MPH, CHES
Health Communications Specialist
Office of Communication and Knowledge Transfer
Agency for Healthcare Research & Quality
Rockville, MD


Carolyn LePage, PhD, ARNP
Assistant Professor
Barry University School of Nursing
Miami Shores, FL

Peer Reviewer

Joyce M Knestrick, PhD, CRNP, FAANP
Coordinator of Graduate Education
Frontier School of Midwifery and Family Nursing
Certified Family Nurse Practitioner
The Primary Care Center
Mt Morris, PA

Peer Reviewer

Kathleen A Jarvis, MS, RN, CCM
Clinical Educator
Alere Healthcare
Fort Lauderdale, FL

Peer Reviewer

Scott A Strassels, PharmD, PhD, BCPS
Healthcare Policy and Economic Outcomes
Mallinckrodt Pharmaceuticals
St. Louis, MO

Peer Reviewer

Wendy L Bennett, MD, MPH
Assistant Professor of Medicine
Population, Family and Reproductive Health
Bloomberg School of Public Health
Johns Hopkins Medicine
The Johns Hopkins University
Baltimore, MD

Begin Activity

Accreditation/Credit Designation

Physician Credit Designation Statement

A C C M E Logo

PRIME Education, Inc. (PRIME®) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

PRIME® designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Physician Assistant Accreditation Statement

AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME. Physician assistants may receive a maximum of 1.0 hours of Category I credit for completing this program.

Nurse Practitioner Accreditation Statement

Nurse Practitioner Logo

PRIME Education, Inc (PRIME®) is approved as a provider of Nurse Practitioner Continuing Education by the American Association of Nurse Practitioners. Provider number: 060815. This program is accredited for 1.0 contact hour. Program ID# CER30.

This program was planned in accordance with AANP CE Standards and Policies and AANP Commercial Support Standards.

Pharmacist Accreditation StatementA C P E Logo

PRIME® is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This curriculum has been approved for 1.0 contact hour (0.1 CEUs) by PRIME®. The Universal Activity Number for this program is 0255-0000-12-020-H04-P. This learning activity is Knowledge-Based.

Nurse Accreditation StatementA N C C Logo

PRIME Education, Inc. (PRIME®) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

PRIME® designates this activity for 1.0 contact hour.

Case Manager Accreditation Statement

The Commission for Case Manager Certification designates this educational activity for 1.0 contact hour for certified case managers.

Medical Assistant Accreditation Statement

This program has been granted prior approval by the American Association of Medical Assistants (AAMA) for 1.0 Continuing Education unit. Approval #122515. Granting approval in no way constitutes endorsement by the AAMA of the program content or the program's sponsor.

Certified Health Education Specialist Accreditation Statement

Sponsored by PRIME Education, Inc. (PRIME®), a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc.

This program is designated for Certified Health Education Specialists (CHES) to receive up to 1.0 Category I contact hours in health education.

CHES Provider Number: MEP3774

Begin Activity

Faculty Disclosures

Faculty Name
Advisory Board Consultant Grants / Research Salary / Contractual Supported Promotional Education Stock / Shareholder Other Financial Support
C Michael White PharmD, FCP, FCCP
None None None None None None None
L. Natalie Carroll, MD, FACOG
None None None None None None None
Lucy N Marion, PhD, RN, MN, FAAN
None None None None None None None
Barbara L Kass, MPH, CHES
None None None None None None None
Carolyn LePage, PhD, ARNP
None None None Barry University None None None
Joyce M Knestrick, PhD, CRNP, FAANP
None None None None None None None
Kathleen A Jarvis, MS, RN, CCM
None None None None None None None
Scott A Strassels, PharmD, PhD, BCPS
None None Endo Pharmaceuticals, Johnson & Johnson None None None None
Wendy L Bennett, MD, MPH
None None None None None None None
Chris R Prostko, PhD
Scientific Program Director
Lynn Goldenberg, RN, BSN
Director of Accreditation & Compliance

Disclosure Policy

PRIME Education Inc (PRIME®) endorses the standards of the ACCME, as well as those of the AANP, ANCC and ACPE, that require everyone in a position to control the content of a CME/CE activity to disclose all financial relationships with commercial interests that are related to the content of the CME/CE activity. CME/CE activities must be balanced, independent of commercial bias and promote improvements or quality in healthcare. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession.

A conflict of interest is created when individuals in a position to control the content of CME/CE have a relevant financial relationship with a commercial interest which therefore may bias his/her opinion and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks or other financial benefits.

PRIME® willidentify, review and resolve all conflicts of interest that speakers, authors, course directors, planners, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for speakers, authors, course directors, planners, peer reviewers, and/or relevant staff are provided with this activity.

Presentations that provide information in whole or in part related to non FDA approved uses of drugs and/or devices will disclose the unlabeled indications or the investigational nature of their proposed uses to the audience. Participants should refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Participants should verify all information and data before treating patients or employing any therapies prescribed in this educational activity. The opinions expressed in the educational activity are those of the presenting faculty and do not necessarily represent the views of PRIME®, the ACCME, AANP, ACPE, ANCC and other relevant accreditation bodies.

Content validation methods are consistently utilized by PRIME® to ensure that all program content is evidence-based, fair-balanced, and developed with scientific rigor and integrity. All clinical recommendations are based on evidence accepted within the medical profession. All scientific research referred to, reported or used to support a clinical recommendation conforms to accepted standards of experimental design, data collection and analysis. In addition to review of content by course directors and expert faculty, content is also validated through independent peer reviewers selected for their expertise in the content area, as well as their experience in the intended audience. All peer reviewers, planners, course directors, faculty and relevant staff utilized by PRIME® complete disclosures which are related to their role in the educational activity.


PRIME®is committed to providing access to our CME programs for individuals with disabilities as identified in Section 508 of the Rehabilitation Act for all web-based programs. This website is 508 compliant.

Begin Activity


To access the activity, please complete this brief Pretest.

  • Returning user? Login Here!
  1. Before accessing this educational activity, were you aware of the AHRQ-supported comparative effectiveness research on various topics?

  2. Which of the following steps follows the posting of a research abstract or set of questions in AHRQ’s EHC Program Research Process?

  3. Which of the following domains is required for grading the evidence in AHRQ's EPC systematic reviews?

  4. Which of the following is an important factor to consider for shared and informed decision making between the health professional and patient?

  5. How would you describe your current level of confidence in applying comparative effectiveness research?

  6. How valuable is comparative effectiveness research in making patient-centered treatment and management decisions?

  7. If you had a clinician guide/consumer guide for any topic, what would you most likely do?

  8. You are a stakeholder involved in the process of conducting research for AHRQ’s comparative effectiveness review. In which of the following ways could you actively engage and become involved as a key informant in the comparative effectiveness research process?

Post-Test & Evaluation

You must access the activity before receiving credit!