- CME/CE Activities
- Comparative Effectiveness in Type 2 Diabetes
This CME/CE activity is provided by PRIME Education, Inc. (PRIME®) and is accredited for a multi-disciplinary audience of health care practitioners. This activity is supported by contract number HHSA290201200021I from the Agency for Healthcare Research and Quality. User data collected through this activity will reside on PRIME's educational portal for use by AHRQ.
AHRQ's Comparative Effectiveness Research on Premixed Insulin Analogues for Adults with Type 2 Diabetes: Understanding and Applying the Systematic Review Findings
- Program Overview
- Faculty Biographies
- Accreditation Statements
- Post-Test & Evaluation
Credit for this CME/CE activity has expired.
You can still access the program, but will not receive a certificate.
Among people with type 2 diabetes who have severe pancreatic β-cell dysfunction, exogenous insulin treatment is essential for controlling glycemia and reducing risks of disease-related complications and mortality. Conventional human insulin preparations can be limited by their slow absorption and inability to adequately match the complex basal-bolus pattern of physiologic insulin activity. The development of insulin analogues, including premixed formulations that are designed to mimic physiologic insulin activity, has advanced diabetes management and afforded patients more convenient treatment options. Until recently, however, the benefits and harms of premixed insulin analogues had not been compared with outcomes of other insulin therapies and noninsulin oral antidiabetic agents. In 2008, under the auspices of the Agency for Healthcare Research and Quality (AHRQ), a systematic review on this topic was published.
This e-JMCP article is intended to familiarize health care professionals with the methods and key findings from AHRQ's comparative effectiveness research and systematic review on premixed insulin analogues. In addition, the article offers reflections on how the findings might be applied in clinical and managed care settings.
At the conclusion of this activity, the participant should be able to:
- Compare the effectiveness, safety, and adherence outcomes of using premixed insulin analogues versus other insulin preparations for achieving optimal glycemic control in type 2 diabetes
- Differentiate the effectiveness and safety of premixed insulin analogues across various subpopulations of patients with type 2 diabetes
- Interpret the effectiveness and safety of premixed insulin analogues in patients receiving oral diabetes medications and with different blood glucose patterns or intensities of control
- Apply AHRQ's systematic review findings on premixed insulin analogues to making patient-centered treatment and management decisions
This CME activity is designed to meet the educational needs of physicians, pharmacists, nurses, and case managers who manage patients with diabetes.
Method of Participation
To receive a certificate for this activity, you should:
- Complete the learner assessment pretest
- View the entire activity online
- Complete an online evaluation & post-test
- Print your certificate online
The estimated time to complete this activity, including review of the materials, is 2.5 hours.
Term of Approval
March 31, 2011 through March 30, 2013. Original release date: March 31, 2011.
Acknowledgement of Support
There is no fee for this CME/CE activity. This activity is sponsored by PRIME Education, Inc (PRIME®) and funded under contract HHSA290201200021I from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health and Human Services (HHS).
Faculty Biographies and Disclosures
Assistant Professor of Medicine
Division of General Internal Medicine/Hospitalist Program
Johns Hopkins School of Medicine
Lead investigator of the AHRQ's diabetes systematic review in comparative effectiveness research of premixed insulin analogues
Diana I Brixner, RPh, PhD
Professor and Chair Department of Pharmacotherapy
Executive Director of the Pharmacotherapy Outcomes Research Center
University of Utah College of Pharmacy
University of Utah
Salt Lake City, UT
Karen M Gunning, PharmD, BCPS, FCCP
Adjunct Associate Professor of Family & Preventive Medicine
University of Utah
College of Pharmacy
Department of Pharmacotherapy
Salt Lake City, UT
Laurence Greene, PhD
Director of Scientific Education and Outcomes
PRIME Education, Inc.
Heidi Wynn Maloni, PhD, ANP-BC, CNRN, MSCN
National Clinical Nursing Director
Department of Neurology
Multiple Sclerosis Center of Excellence, East
Veterans Affairs Medical Center
Trinity Nursing Program School of Professional Studies
Trinity Washington University
Clinical Preceptor and Instructor
Advanced Practice Programs
The Catholic University of America School of Nursing
Michele B Kaufman, PharmD, CGP, RPh
President, PRN Communications Inc.
Editor, Pharmacovigilance Forum, P&T Journal
Touro College of Pharmacy
New York, NY
Arshag D Mooradian, MD
Professor and Chairman
Department of Medicine
University of Florida College of Medicine
Brian J Quilliam, PhD, RPh
University of Rhode Island College of Pharmacy
Connie A Valdez, PharmD, MSEd, BCPS
University of Colorado School of Pharmacy
Joshua J Neumiller, PharmD, CDE, CGP, FASCP
Department of Pharmacotherapy
College of Pharmacy
Washington State University/Elder Services
R Keith Campbell, RPh, FASHP, FAPhA, CDE
Distinguished Professor in Diabetes Care/Pharmacotherapy
Washington State University College of Pharmacy
Kathleen A Jarvis, MS, RN, CCM
Fort Lauderdale, FL
This program is no longer accredited.
|Faculty Name ||Advisory Board||Consultant||Grants / Research||Salary / Contractual||Supported Promotional Education||Stock / Shareholder||Other Financial Support|
|Diana I Brixner, RPh, PhD
|None||novo nordisk, novartis, abbott||None||None||None||None||None|
|Karen M Gunning, PharmD, BCPS, FCCP
|Laurence Greene, PhD
|Heidi Wynn Maloni, PhD, ANP-BC, CNRN, MSCN
|Michele B Kaufman, PharmD, CGP, RPh
|Arshag D Mooradian, MD
|Brian J Quilliam, PhD, RPh
|None||None||research funding to University of RI from Takeda and Ortho McNeil Janssen||None||None||None||None|
|Connie A Valdez, PharmD, MSEd, BCPS
|Joshua J Neumiller, PharmD, CDE, CGP, FASCP
|None||None||research funding to Washington University from Amylin, Johnson and Johnson, Merck, NovoNordisk||Washington University||None||None||None|
|R Keith Campbell, RPh, FASHP, FAPhA, CDE
|Kathleen A Jarvis, MS, RN, CCM
|Chris R Prostko, PhD|
Scientific Program Director
|Lynn Goldenberg, RN, BSN|
Director of Accreditation & Compliance
PRIME Education Inc (PRIME®) endorses the standards of the ACCME, as well as those of the AANP, ANCC and ACPE, that require everyone in a position to control the content of a CME/CE activity to disclose all financial relationships with commercial interests that are related to the content of the CME/CE activity. CME/CE activities must be balanced, independent of commercial bias and promote improvements or quality in healthcare. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession.
A conflict of interest is created when individuals in a position to control the content of CME/CE have a relevant financial relationship with a commercial interest which therefore may bias his/her opinion and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks or other financial benefits.
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Presentations that provide information in whole or in part related to non FDA approved uses of drugs and/or devices will disclose the unlabeled indications or the investigational nature of their proposed uses to the audience. Participants should refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Participants should verify all information and data before treating patients or employing any therapies prescribed in this educational activity. The opinions expressed in the educational activity are those of the presenting faculty and do not necessarily represent the views of PRIME®, the ACCME, AANP, ACPE, ANCC and other relevant accreditation bodies.
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Post-Test & Evaluation
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Clinician & Consumer Summaries on Premixed Insulin Analogues
Download these free summaries for your reference and/or patient handouts. You may also order bulk copies free of charge from the AHRQ Publication Clearinghouse below.